Journal article

Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry

GS Dite, E Makalic, DF Schmidt, GG Giles, JL Hopper, MC Southey

Breast Cancer Research | BIOMED CENTRAL LTD | Published : 2012

Abstract

Introduction: We hypothesised that breast cancer risk for relatives of women with early-onset breast cancer could be predicted by tumour morphological features.Methods: We studied female first-degree relatives of a population-based sample of 452 index cases with a first primary invasive breast cancer diagnosed before the age of 40 years. For the index cases, a standardised tumour morphology review had been conducted for all; estrogen (ER) and progesterone receptor (PR) status was available for 401 (89%), and 77 (17%) had a high-risk mutation in a breast cancer susceptibility gene or methylation of the BRCA1 promoter region in peripheral blood DNA. We calculated standardised incidence ratios ..

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Grants

Awarded by National Institutes of Health


Funding Acknowledgements

We would like to thank the study pathologists Dr Jane Armes, Dr Deon Venter, Dr Elena Provenzano, Dr Sarbar Napaki and Dr Beena Kumar who reviewed archival tumour materials for the Australian Breast Cancer Family Registry (ABCFR). We wish to thank Margaret McCredie for her key role in the establishment and leadership of the ABCFR in Sydney, Australia. The ABCFR has been supported in Australia by the National Health and Medical Research Council, the New South Wales Cancer Council, the Victorian Health Promotion Foundation, the Victorian Breast Cancer Research Consortium, Cancer Australia and the National Breast Cancer Foundation. The ABCFR has also been supported by the National Cancer Institute, National Institutes of Health, USA under RFA CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry: The University of Melbourne, Melbourne, Victoria, Australia (U01 CA69638), Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA (U01 CA69631), Huntsman Cancer Institute, Salt Lake City, Utah, USA (U01 CA69446), Columbia University, New York, New York, USA (U01 CA69398), Cancer Prevention Institute of California, Fremont, California, USA (U01 CA69417), and Cancer Care Ontario, Toronto, Ontario, Canada (U01 CA69467). The content of this article does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres of the Breast CFR. The mention of trade names, commercial products or organisations does not imply endorsement by the US government or the Breast Cancer Family Registry.